Buffalo Bills vs San Francisco 49ers Prediction, Line. Buffalo 27, San Francisco 24 Bet on Buffalo vs San Francisco with BetMGM San Francisco -1, o/u: 47 ATS Confidence out of 5: 2.5. Must See Rating: 3.5. 5: Gangs of London 1: Hillbilly Elegy. Buffalo Bills vs San Francisco 49ers prediction, game preview, and fantasy player to watch. Buffalo Bills vs San Francisco 49ers Broadcast Date: Sunday, December 7 Game Time: 8:15 ET Venue: State.

• Bills 49ers Prediction Score
• Bills 49ers Prediction Super Bowl

The 49ers come into Week 13 with a 1-4 SU and ATS record at home for the year, having failed to score more than 24 points in any home game in 2020. NFL Prediction: Who Will Win Bills vs. Prediction: 49ers 24, Bills 20 — Written by Matt Josephs, who is a part of the Athlon Sports Contributor Network. Follow him on Twitter @MidMajorMatt.

Game: Buffalo Bills vs San Francisco 49ers

Date: Monday, December 7, 2020

Location: State Farm Stadium in Glendale, AZ

TV: ESPN

Odds/Point Spread: San Francisco +2.5

Total/Over-Under: 48

Nick Mullens and the San Francisco 49ers (5-6) host the Buffalo Bills (8-3) at State Farm Stadium on Monday, December 7, 2020. San Francisco opens this game as 2.5-point dogs. The over/under opens at 48.

The Buffalo Bills come into this matchup with a record of 8-3 for this season. In their last game they faced the Los Angeles Chargers and earned the victory by a score of 27-17. Josh Allen went 18/24 with 157 yards passing and added 1 touchdown. He tossed 1 pick during the game. Devin Singletary led the team in rushing for the game. He had a long run of 24 yards but wasn't able to convert a rushing touchdown. He ran for a total of 82 yards by way of 11 carries which had him averaging 7.5 yards per run. Gabriel Davis was the leader in receiving yardage with a tally of 79 yards on 3 catches. He earned an average of 26.3 yards per catch for the game. The Buffalo Bills ran the ball 30 times and racked up 172 yards earning them an average of 5.7 yards per rush. In the game, they ran 58 plays for a total of 332 yards. For the game, the Bills totaled 23 1st downs and they had 9 penalties for 85 yards. In terms of defense, Buffalo allowed 31 catches on 52 tries totaling 291 yards, and a completion percentage of 60.0%. Against the run, the Bills allowed 76 yards on 24 carries which is an average of 3.2 yards per attempt allowed. For the game, they gave up 367 yards and earned 1 turnover.

The Bills currently have 4,097 yards in total over the course of this season. As a team they're holding an average of 104.4 yards on the ground ranking this team at 22nd in the National Football League. When it comes to scoring, Buffalo has amassed 24 touchdowns through the air and 10 touchdowns on the ground. Regarding scoring, the Buffalo Bills have an average of 27.2 points per contest. Concerning passing yards, the Bills have conceded 2,678 yards which ranks them 18th in the NFL. For the season, they have relinquished 373.1 yards per contest which has them ranked 21st in the league. The Bills sit in 18th in the league in relation to their opponents scoring, allowing 25.6 PPG. They are giving up 4.7 yards per run and 129.6 rushing yards per contest this season. Over the course of their 11 games played, they have surrendered 243.5 yards per contest via the pass as well as allowing a completion percentage of 66.8%. During this campaign, they have given up 1,426 rushing yards through 11 outings.

The 49ers head into this matchup 5-6 for this season. In their last contest they played the Los Angeles Rams and won by a score of 23-20. Raheem Mostert paced the team in rushing for the game. He tore off a long run of 10 yards and he added 1 TD for the game. He scurried for 43 yards on 16 carries which meant he averaged 2.7 yards per run. Deebo Samuel led the team in receiving yardage with a total of 133 yards on 11 receptions. He had an average of 12.1 yards per catch for the game. Nick Mullens went 24/35 with 252 yards through the air but wasn't able to get any balls in the endzone via the pass. He gave away 1 interception in the game. The San Francisco 49ers ran the ball 33 times and earned 115 yards which had them averaging 3.5 yards per carry. On the day, the 49ers racked up a total of 18 first downs and they totaled 5 penalties for 40 yards. In all, they ran 70 plays for a total of 348 yards. When discussing the defense, San Francisco allowed 19 catches on 31 throws for a total of 182 yards, and a completion percentage of 61.0%. On the day, they conceded a total of 308 yards and forced 4 takeaways. On the ground, the 49ers allowed 126 yards on 28 tries which is an average of 4.5 yards per attempt allowed.

For the season so far, the 49ers have earned 2,760 passing yards as well as holding an average of 250.9 passing yards per contest, which is ranked 12th in football. The San Francisco 49ers have an average of 363.2 yards per contest ranking them 14th out of all teams in the league. They hold an average of 112.3 rushing yards per game and have rushed for 1,235 yards in total. In terms of this team's ability to score points, the 49ers are ranked 20th in the league scoring 23.7 PPG. The 49ers are sitting in 11th in the NFL when it comes to team defense, giving up 23.1 PPG. They are giving up 4.0 yards per rushing attempt and 108.7 rushing yards per contest this season. Over the course of this season, they have conceded 1,196 yards on the ground through 11 contests. When it comes to yards via the pass, the 49ers have given up 2,271 yards which ranks them 5th in football. In their 11 games played this year, they are giving up 206.5 yards per contest via the pass in addition to conceding a completion percentage of 64.6%. Overall, they are allowing 315.2 yards/outing ranking them 6th in the National Football League.

Who will win tonight's Bills/49ers NFL game against the spread?

Tony's Pick: Take the Bills -2.5

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• December 7, 2020
• By Matt Blunt
• VegasInsider.com

Bills vs. 49ers - Predictions

• Score Prediction: San Francisco 24 Buffalo 21
• Best Bet: 49ers PK

We get another Monday Night doubleheader this week thanks to all the scheduling changes this league has had recently, but the game that was always slated to be in this spot is the non-conference tilt between the Bills and 49ers.

The two teams come into this game with very different goals, as San Francisco is trying to scratch and claw it's way back to a playoff spot to at least have a shot at defending their NFC title, while Buffalo's trying to fend off the Dolphins in the AFC East race.

Miami is expected to take care of their business rather easily on Sunday in hosting the Bengals, so theoretically, Buffalo could come into this MNF affair tied atop the division. That provides a whole different type of sweat to all those bettors that were certain Buffalo would win the AFC East this year because the Patriots wouldn't.

The latter half of that hypothesis will likely come true, but Buffalo still has their hands full with Miami trying to hunt them down with both teams having very tough home games on deck next week (Buffalo hosts Pittsburgh, Miami hosts KC) with a Week 17 showdown between the two AFC East rivals looking like it may decide the division.

That means we are likely to see Josh Allen and his Buffalo Bills teammates quite frequently under the prime time lights this month. Can we start that run with a winner in this MNF game against a Niners team with just as much to fight for right now.

Betting Resources

• Week 13 Matchup: AFC vs. NFC
• Expert Picks:Vegas Insiders
• Venue: State Farm Stadium
• Location: Glendale, Arizona
• Date: Monday, Dec. 7, 2020
• Time: 8:15 p.m. ET
• TV: ESPN
• Bet:BetMGM BetRivers FanDuel PointsBet All California Sports Betting

Bills-49ers Betting Odds

Odds Subject to Change

2020 Betting Stats

(Straight Up - SU, Against the Spread - ATS, Over-Under - O/U)

Buffalo

• Overall: 8-3 SU, 6-5 ATS, 7-3-1 O/U
• Road: 3-2 SU, 2-3 ATS, 3-1-1 O/U
• Offense PPG: 27.2 (Rank 10)
• Defense PPG: 25.6 (Rank 18)
• Offense YPG: 372.5 (Rank 11)
• Defense YPG: 373.1 (Rank 21)

San Francisco

• Overall: 5-6 SU, 5-6 ATS, 5-6 O/U
• Home: 1-4 SU, 1-4 ATS, 2-3 O/U
• Offense PPG: 23.7 (Rank 20)
• Defense PPG: 23.1 (Rank 11)
• Offense YPG: 362.9 (Rank 14)
• Defense YPG: 315.2 (Rank 6)

Over vs. Under
Handicapping the Total

With all the injuries the 49ers have dealt with this season, clawing their way back into a playoff spot in the NFC would be quite the huge accomplishment. QB Jimmy Garoppolo and TE George Kittle have both been out since Week 8 for the 49ers, and head coach Kyle Shanahan was hopefully, but non-committal, this week in talking about hopefully getting both of those guys back for the final few weeks of the year.

If that's indeed on the table, San Francisco has got to do their best to make those games mean something for this year, and that means taking care of business each and every week until then. Those two players shouldn't be considered saviours of the organization by any means, but Kittle especially is a huge upgrade at his position.

I bring all this up because we've already seen some early support for the 49ers this week, as an opening number of +2.5 on San Fran has been bet down to it's current standing. Clearly the 49ers side is something bettors have little issue getting behind and if a SF win is on the horizon here, 49ers wins this year have been correlated with San Francisco playing quite well defensively.

San Fran is 2-3 O/U in their five victories this year, but the two 'overs' came in Weeks 2 and 3 of the season during their two-week stay in New York to beat up on the Jets and Giants. Those games barely got 'over' the number with San Francisco scoring 31 and 36 points themselves in those games.

Which brings me to the point totals of those foes the 49ers have vanquished this year. They held the Jets to 13, the Giants to 9, the Rams to 16 and 20 (swept the season series), and the Patriots to 6 points.

That five-game average of 12.8 points allowed in wins is spectacular for the 49ers, and you've got to figure that with far fewer weapons available to them relative to the Bills, any 49ers win will have some correlation to another strong defensive game by them.

Defense is something the Bills have improved on recently, at least in terms of getting off the field on 3rd down. Through their past three games, Buffalo's defense ranks 4th in opponent third down conversion percentage (26.83%), trailing just the Steelers, Giants (oddly enough) and Saints in that category.

For Buffalo to put up those numbers when their three opponents in that stretch were Seattle, Arizona, and the Chargers, it's an improvement that can't be overlooked in the slightest.

The 49ers are just a few spots behind Buffalo in that regard as well, sitting 8th in opponent 3rd down conversion percentage over their last three games too (32.43%).

Those defensive numbers for Buffalo tend to get lost in the fact that they've given up Hail Mary completions in each of their last two games overall, costing them a win (and subsequent breathing room in the AFC East) in the process. Add in the fact that Seattle put up 34 on the Bills as well, and the Chargers deserving more than the 17 points they scored a week ago, and the reputation of Buffalo being an 'over' team this season is going to be hard to shake for some.

Buffalo's 7-0-1 O/U run off a win, and 7-3-1 O/U record this year feeds into those 'over' leans already, but in the previous (2) times the Bills have found themselves in the stand alone game spotlight (Tuesday vs Tennessee in Week 5, and Monday in Week 6 vs KC) they put up 16 and 17 points respectively.

A lot more variables went into those two games, not the least of which being they were up against two very good teams there, but this Bills team that most of the market has been waiting on (and anointing) to finally take that next step, always seem to put their worst foot forward when they reach the foot of that step.

Put it all together and the only way to look at this total would be to go low here. Buffalo's 'over' record is in part why this number appears to be a shade to high in my view, as Buffalo's woeful defense from earlier in the year still holds a lot of weight in any narrative surrounding a Bills game.

The fact that Buffalo's recent 3rd down improvement on defense gets lost in the higher scores and inability to defense Hail Mary's is another factor in having this total where it is, but it's also not Russell Wilson, Kyler Murray, or Justin Herbert they are going up against. It's Nick Mullens. Enough said.

Under or pass.

Head-to-Head History

• Oct. 16, 2016 - Buffalo 45 vs. San Francisco 16, Bills -7.5, Over 44
• Oct. 7, 2012 - San Francisco 45 vs. Buffalo 3, 49ers -10, Over 45.5
• Nov. 30, 2008 - San Francisco 10 at Buffalo 3, 49ers +6.5, Under 43

Bills vs. 49ers
Handicapping the Side

Can't ignore this strong move the 49ers way and admittedly it does contribute to the 'under' thinking as well on the total.

But when you have a team like Buffalo who you know is going to be the default pick for many on Monday night simply based on team records and having their starting QB, the fact that an opening number of -2.5 on Buffalo never came close to going up to -3 with (likely) majority support is rather telling.

Bills 49ers Prediction Score

Oddsmakers clearly never wanted to hang a +3 on San Fran up there fearing a wave of 49ers money and it came anyways without even reaching that key number.

It's alright to like the 49ers side using that line move as support, but tough to confidently back them now at a far worse price, with no real opportunity to buy a half-point to artificially get a +3 ticket on San Francisco in hand. Remember, it's the 49ers who are the more desperate team in needing every win they could get right now, and there is always the possibility of Buffalo peaking ahead to that showdown with the undefeated Steelers next week.

Makes this side an easy one to pass on all the way around now, instead looking to go the live betting route in taking points with probably either side if the game flow feels right to do so. It's been three straight ATS wins for Buffalo these past three weeks – but they've also been outgained in total yards in three of their last four, the lone outlier being the win over Seattle where Buffalo had one more total yard.

If they get outgained by this mash group of 49ers on offense, chances are that early San Francisco money is going to be smiling come Tuesday morning. Let's not forget that Buffalo is also on a 1-4 ATS run against a team with a losing record, and 0-3-1 ATS in their last four appearances on MNF too.

Key Injuries

Buffalo

• LB Matt Milano: Pectoral - Questionable
• TE Tyler Kroft: Quarantine - Questionable
• T Cody Ford: Ankle - Out
• WR John Brown: Ankle - Out

San Francisco

• RB Tevin Coleman: Knee - Probable
• WR Deebo Samuel: Hamstring - Probable
• LB Demetrius Flannigan-Fowles: Hamstring - Questionable
• OL Tom Compton: Concussion - Questionable
• CB Jamar Taylor: Knee - Out
• CB K'Waun Williams: Suspension - Out

2020 Monday Night Football (MNF) Betting Results

Betting Results

Straight Up (SU), Against the Spread (ATS)

• Home-Away: 4-8 SU, 7-5 ATS
• Favorites-Underdogs: 8-4 SU, 5-7 ATS
• Over-Under: 5-7

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Bills 49ers Prediction Super Bowl

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